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Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde. The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis.
The study contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed. The findings also may help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.
“Factors like binge drinking have been linked to increased risk for heart disease, and the newer inflammatory model is beginning to explain how,” study leader John Cullen, an assistant professor in the department of surgery, said in a medical center news release. “One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”
The study was published in the current issue of the journal Atherosclerosis.
Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism. Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.
An estimated 65 percent of Americans drink alcohol, and 15 percent reporting binge patterns, the researchers said.
VANCOUVER – Health workers on Vancouver’s Downtown Eastside say they have complained for years about drug addicts being offered kickbacks from pharmacists to fill their methadone prescriptions, a problem they say is getting worse. “We all know about it. The clients know about it, we know about it, but it’s like it’s falling on deaf….
Most people who are seeking a drug rehab center and are fortunate enough to have health insurance want to know if it will by for the treatment. While there isn’t really a simple answer to this, there are some basic guidelines here that can help you understand the process a bit more and how it….
The list of disorders is very unending. There are various different disorders that can be contracted by an individual. Most of the disorders largely affect the mental health of the patient. Bi-polar disorder is a similar type of disease affecting a large number of the total population around the world. Scientifically the Bi-polar disorder is….
Call it the chicken-and-egg debate of the addiction world: Cocaine addicts are known for being frenetic, but which came first, the behavior or the habit? New research indicates that, at least in rats, it’s the behavior that begets addiction. What’s more, the study has pinpointed the character trait–impulsiveness–that is responsible for developing true drug dependence…..
A new monthly injection could help keep holiday drinkers on the wagon. David Rosenbloom, a specialist in substance abuse at Boston University School of Public Health, said for people battling alcoholism, holidays pose a strong danger of relapse. “For some it’s the stress of being lonely, for others it’s the stress of being with people,”….