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Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde. The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis.
The study contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed. The findings also may help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.
“Factors like binge drinking have been linked to increased risk for heart disease, and the newer inflammatory model is beginning to explain how,” study leader John Cullen, an assistant professor in the department of surgery, said in a medical center news release. “One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”
The study was published in the current issue of the journal Atherosclerosis.
Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism. Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.
An estimated 65 percent of Americans drink alcohol, and 15 percent reporting binge patterns, the researchers said.
Heroin dependence can lead to serious side effects, overdose or even death if left untreated. Withdrawal during detox can be challenging and dangerous, inpatient heroin treatment centers provide the safest methods of treatment and care. Consider the safety, cost, location, medical care and effectiveness of inpatient heroin addiction treatment before making a final decision. Heroin….
DNA plays a role in the amount of alcohol you drink, researchers say. Among alcohol-dependent (AD) individuals, DNA variations in the brains serotonergic system influence drinking intensity. Specifically the serotonin transporter gene (SLC6A4) contributes to a persons inclination to drink. Researchers analyzed the associations between 275 AD patients seeking treatment and six variations of SLC6A4…..
A study in this month’s Anesthesiology found evidence that alcohol use disorders (AUDs) are frequently overlooked in patients undergoing surgery ― but also touts a very simple and effective method to identify patients who may be at risk for alcohol-related perioperative complications. In the AUD study, anesthesiologist Claudia D. Spies, M.D., and her research group….
When Luis Carino was sober, his friends said he was a thoughtful guy. He painted and fixed things and did odd jobs for people in the neighborhood where he used to live. But when he drank beer, which friends said was often, it was a different story. Carino, 52, who had a history of battery,….
Binge-drinking not only causes a hangover but weakens the body’s ability to fight off infections for at least 24 hours, research has shown. Drinking large amounts of alcohol in a short time inhibits the production of signalling molecules that are vital to the immune system. The proteins, known as pro-inflammatory cytokines, have a host of….