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Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde. The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis.
The study contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed. The findings also may help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.
“Factors like binge drinking have been linked to increased risk for heart disease, and the newer inflammatory model is beginning to explain how,” study leader John Cullen, an assistant professor in the department of surgery, said in a medical center news release. “One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”
The study was published in the current issue of the journal Atherosclerosis.
Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism. Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.
An estimated 65 percent of Americans drink alcohol, and 15 percent reporting binge patterns, the researchers said.
Alcoholism – one of the main reasons behind deadly road accidents, assaults and increasing cases of domestic violence – has been deteriorating the life of millions of people across the globe. Alcohol, when consumed, may relax you and give you the feeling of being less anxious, but you should not forget that it has direct….
Ensuring Solutions has come up with some sobering facts about alcohol abuse and its impact in almost all facets of our society. Excessive alcohol use by employees and their family members has a substantial impact on the cost of doing business. It costs U.S. employers billions in lost productivity and additional health care costs every….
Substance abuse is spreading rapidly around the world and the number of teens who do substance abuse is increasing at an alarming rate. Teenagers are widely using chemical substances for altering their “mood and physical state”. The use of chemical substances beyond the prescribed limit is bound to make the body of the user dependent….
TORONTO – Laura Adamarczuk was initially blase when asked to complete an online questionnaire to evaluate her drinking habits. The survey was compulsory for residence dons at the University of Western Ontario, but the 21-year-old felt the exercise had minimal value. A student who went out with friends about twice a week was, after all,….
When a loved one is addicted to methamphetamine the most important thing to do is get them into treatment immediately. Crystal meth, also known as glass or methamphetamine, is a dangerous drug and a meth addiction is a widely growing problem throughout the United States. Methamphetamine addiction is a very dangerous condition that requires immediate….
