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Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde. The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis.
The study contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed. The findings also may help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.
“Factors like binge drinking have been linked to increased risk for heart disease, and the newer inflammatory model is beginning to explain how,” study leader John Cullen, an assistant professor in the department of surgery, said in a medical center news release. “One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”
The study was published in the current issue of the journal Atherosclerosis.
Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism. Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.
An estimated 65 percent of Americans drink alcohol, and 15 percent reporting binge patterns, the researchers said.
There are many risks involved with underage drinking. Possibly the scariest is the lack of understanding about alcohol and what it does to the body. Underage drinkers have no concept of the damage drinking too much can have or even what constitutes “a drink”. 14 grams of pure alcohol is a standard drink: which is….
Homeless, alcoholic and hopeless, Dan Oller arrived last year at the Charlotte Rescue Mission, skeptical that its addiction treatment program could help him when 11 others had not. “There’s always that doubt in your mind, once you’ve failed over and over,” said Oller, who started drinking and doing drugs when he was 12. “I was….
While Britain tries a new approach to curb underage drinking, teenage binges are on the rise across the Channel If there is one country that might be expected to greet the chief medical officer’s words on not mixing children and alcohol with a loud cough and splutter, it is France. In the land of rolling….
Anyone who has dealt closely with addiction knows that it is a terrible disease. Those who live with addiction struggle with temptation, shame and guilt as a result of their addiction to a point in which is totally disrupts any chance at a normal lifestyle. Treatment for addiction is based on medical approaches, scientific advancements….
Richard started drinking a few glasses of red wine in the evening to relax and pass the time. But gradually a couple of glasses turned into a bottle – and then two. Without realising it Richard, a 51-year-old professional, was soon drinking 126 units a week – four and a half times more than the….
