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Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde. The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis.
The study contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed. The findings also may help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.
“Factors like binge drinking have been linked to increased risk for heart disease, and the newer inflammatory model is beginning to explain how,” study leader John Cullen, an assistant professor in the department of surgery, said in a medical center news release. “One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”
The study was published in the current issue of the journal Atherosclerosis.
Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism. Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.
An estimated 65 percent of Americans drink alcohol, and 15 percent reporting binge patterns, the researchers said.
The reality of drug or alcohol addiction is that the addiction is a disease that can ruin lives and ultimately kill the addict. When an individual is addicted to drugs or alcohol they are at risk of getting in trouble with the law, suffering medical problems, ruining relationships with their children or families, losing their….
Elderly treatment is fragile and must be carefully considered before moving forward with care. Seniors often develop drinking problems to cope with loneliness, grief or pain. It is important to choose alcohol addiction treatment centers that have experience in treating the elderly. Substance abuse among the elderly is one of the fastest growing health problems….
Narcotics anonymous is a 12-step program that is implemented for the early recovery of an individual who is highly prone towards doing substance abuse. It is a community and an association to recover the drug addicts. It is non-profit organization established for those men and women that face drug related problems. The membership in this….
A mother climbs out of the depths of addiction She stood on the sidelines amid the blankets and camp chairs, a petite, brown-haired woman in a monogrammed polo shirt, cheering as her 7-year-old son sprinted down the soccer field. At halftime, she stepped up with a water bottle and pep talk. And after the game….
True to its history of impaired judgment when it comes to handling alcohol, the Indiana General Assembly this year placed narrow business interests ahead of public welfare — and didn’t even do so evenhandedly. Regrettably, Gov. Mitch Daniels signed into law bills to expand Sunday hours for bars, give microbreweries a special dispensation to sell….
