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Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde. The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis.
The study contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed. The findings also may help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.
“Factors like binge drinking have been linked to increased risk for heart disease, and the newer inflammatory model is beginning to explain how,” study leader John Cullen, an assistant professor in the department of surgery, said in a medical center news release. “One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”
The study was published in the current issue of the journal Atherosclerosis.
Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism. Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.
An estimated 65 percent of Americans drink alcohol, and 15 percent reporting binge patterns, the researchers said.
One for the Road, the real-life story of a journalist’s battle with alcohol, sparks debate over the country’s self-image as a nation of moderate wine-lovers The posters, on hoardings across France, show a slightly dishevelled media executive in his 50s, on a jetty, a bag in his hand, a Swiss lake behind, staring with vacant,….
Free beer, dollar pitchers, two for one, three for one, bring your own cup and $1 shots – sweet music to the financially challenged, fun-seeking college student’s ear. Add in a couple games of beer pong, flip cup or quarters and the night is sure to be memorable. But when does binge drinking stop being….
What is an Intervention? An intervention is typically seen when family and friends get together with a loved one who is struggling with a drug or alcohol addiction and is not getting help, or is in denial of their addiction. The basic goal of an intervention is to help the struggling addict understand the effects….
No matter what you do, no matter how hard you try, there will still be challenges in drug treatment that can cause some bumps in the road. Even the most dedicated, most willing and most ready to get sober individual will find drug treatment to be a challenging process that takes strength to carry on—but….
Almost 89% of prisoners with an alcohol problem got no help while behind bars last year, according to figures obtained by The Herald. Despite alcohol being an aggravating factor in more than half of all homicides and much of the violent and anti-social crime which blights Scotland, a tiny proportion of inmates get specialist help….
