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Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde. The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis.
The study contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed. The findings also may help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.
“Factors like binge drinking have been linked to increased risk for heart disease, and the newer inflammatory model is beginning to explain how,” study leader John Cullen, an assistant professor in the department of surgery, said in a medical center news release. “One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”
The study was published in the current issue of the journal Atherosclerosis.
Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism. Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.
An estimated 65 percent of Americans drink alcohol, and 15 percent reporting binge patterns, the researchers said.
At the Barrow Distribution Centre business is brisk, and so it should be as the only place for 200 miles (320 km) where you can get alcohol. Locals trot eagerly up the icy front steps, before emerging to struggle back down laden with cases of beer, bottles of spirits and boxes of red wine. There….
For those who warmly applaud Gordon Brown’s declared desire to toughen up the law on cannabis, raising it from a Class C to Class B drug, there is always a simple question. How would you react if your son, or perhaps your grandchild – otherwise law-abiding and blameless citizens – were caught with that drug….
Alcoholism, like many addictions, is a disease of reinforcement. When you take drugs or alcohol, you feel better and when you stop drinking, you miss the feeling. By this same mechanism, the people you associate with can start to reinforce your drinking behavior. Even though, for many, alcoholism ends up being a disease of solitude….
In Southern California alone, there are hundreds of “Recovery Treatment Programs” or “Drug and Alcohol Rehabs.” Southern California has been ranked the second most popular place in the United States for individuals to seek help, for their drug and alcohol addictions. You have a choice when it comes to women’s drug and alcohol treatment programs….
Nearly 1.4 million New Yorkers abuse or are dependent on alcohol, drugs or both. A new report from the Substance Abuse and Mental Health Services Administration (SAMHSA) provided this and other information about substance abuse and mental health patterns in each state. Rates vary state to state, but all areas of the country are affected….
Calls to numbers on a specific treatment center listing will be routed to that treatment center. Calls to any general helpline will be answered or returned by one of the treatment providers listed, each of which is a paid advertiser: ARK Behavioral Health, Recovery Helpline, Alli Addiction Services.