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Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde. The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis.
The study contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed. The findings also may help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.
“Factors like binge drinking have been linked to increased risk for heart disease, and the newer inflammatory model is beginning to explain how,” study leader John Cullen, an assistant professor in the department of surgery, said in a medical center news release. “One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”
The study was published in the current issue of the journal Atherosclerosis.
Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism. Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.
An estimated 65 percent of Americans drink alcohol, and 15 percent reporting binge patterns, the researchers said.
When the vomiting, tremors, and chills she felt each morning became overwhelming, Jessica Polmann started selling her body to finance her heroin addiction and halt the debilitating physical symptoms of withdrawal. The petite, blond cheerleader, who made the honor roll before she started doing heroin at age 13, received $60 and some cigarettes each time….
Older alcoholics tend to drink heavily more often than younger people, study finds. Older people who are problem drinkers consume more alcohol than their younger counterparts, a new report finds, possibly because they need more alcohol to achieve the same effect. According to a study released this month, people dependent on alcohol who are older….
Measuring a set of protein changes in the blood linked to alcohol use may potentially lead to a more accurate diagnostic test than those currently available, according to Penn State College of Medicine researchers. “The challenge in alcohol abuse as opposed to substance abuse — things like cocaine or heroin or PCP — is that….
Drug abuse is one of the major addictions affecting many people across the world. There is no age limit or gender limitations for drug abuse. Infact, in an official survey, it was found that compared to boys, girls “suffer more from drugs abuse”. This is largely because; teen girls are at “higher risk of depression”. ….
Whether addicted to drugs or alcohol, the physical and psychological effects of addiction can transform a normal everyday person into a shell of what he or she once was. Addictive substances are well known for their ability to alter brain function in such a way as to create a cycle of dependency that becomes all….
