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Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde. The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis.
The study contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed. The findings also may help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.
“Factors like binge drinking have been linked to increased risk for heart disease, and the newer inflammatory model is beginning to explain how,” study leader John Cullen, an assistant professor in the department of surgery, said in a medical center news release. “One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”
The study was published in the current issue of the journal Atherosclerosis.
Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism. Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.
An estimated 65 percent of Americans drink alcohol, and 15 percent reporting binge patterns, the researchers said.
A recent survey found that the number of people who have entered treatment for addiction to benzos such as Valium and Xanax as well as narcotic painkillers such as Oxycodone has increased more than 500% in the past ten years. The overall increase in substance abuse treatment admissions during this period of time was just….
Go on, have another. You’ll be hailing the cab anyway as you’re a bit over the limit now. As for tomorrow, you survived work with a hangover last Tuesday, didn’t you? Besides, it’s your boss offering the next round! Make it a pint. Oh, and mental note: don’t forget to pick up some beer tomorrow….
The epidemic of prescription drug use is a serious one. Most people that abuse prescription drugs are doing so without a doctor’s approval. They are using their medication in other ways other than prescribed by a doctor. Some may also be getting it from someone else. This can lead to drug dependence and addiction. According….
Radiotherapy is also commonly known as radiation therapy, which is also used for cancer treatment. As the name suggests, radiotherapy involves the use of radiations, the ionizing radiations, for treating cancer. These ionizing radiations “injure or destroy” the affected cancerous cells, hampering their “growth” and “division”. It is likely, the normal cells also being damaged,….
CAN THE WAY you chew a raisin affect the way you experience pain? Trials at St James’s and AMNCH (Tallaght) Hospitals in Dublin are beginning to look at how “mindfulness meditation” can be used to help people cope with a diverse range of problems including chronic pain, depression, anxiety, cardiac difficulties and even psoriasis. “Mindfulness….
