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Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde. The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis.
The study contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed. The findings also may help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.
“Factors like binge drinking have been linked to increased risk for heart disease, and the newer inflammatory model is beginning to explain how,” study leader John Cullen, an assistant professor in the department of surgery, said in a medical center news release. “One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”
The study was published in the current issue of the journal Atherosclerosis.
Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism. Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.
An estimated 65 percent of Americans drink alcohol, and 15 percent reporting binge patterns, the researchers said.
Treatment that combines sertraline and naltrexone appears to be superior to treatment with either drug alone, as well as to placebo, for individuals with depression and alcohol dependence. Patients receiving the combination treatment were more likely to achieve abstinence and had delayed relapse to heavy drinking, according to a report posted in the March 15….
When I attend meetings of Alcoholics Anonymous, I speak of my “experience, strength and hope.” As an alcoholic in recovery, I carry that message to others as part of the 12-step program I work in AA. This week, I listened to other voices, both younger and older, carry the message, too, from as near as….
It is the need of today’s individual to remain in perfect appealing shape. The mindset of an individual is inclining more towards his appearance rather than his health. The people with wide waist dimensions are laughed at and those with thin and perfect features are appreciated. This social pressure has made an individual fall pray….
Indian American women who are struggling with alcohol dependence, depression or substance abuse face unique challenges, according to a team of recovery professionals who are targeting the community. “Living here in the U.S. is a very major stress,” Arun Jethanandani, M.D., told India-West by phone from the Brookhaven Retreat in eastern Tennessee. “Many women have….
Colombia’s drug barons used to favour high-speed powerboats to export their deadly cargos, leading law enforcers on high-speed chases as they swamped America with narcotics. Now, in an attempt to evade American surveillance, they are diverting their smuggling trade beneath the waves. Coast Guard and military patrols have reported a dramatic increase in do-it-yourself “semi-submersible”….
