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Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde. The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis.
The study contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed. The findings also may help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.
“Factors like binge drinking have been linked to increased risk for heart disease, and the newer inflammatory model is beginning to explain how,” study leader John Cullen, an assistant professor in the department of surgery, said in a medical center news release. “One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”
The study was published in the current issue of the journal Atherosclerosis.
Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism. Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.
An estimated 65 percent of Americans drink alcohol, and 15 percent reporting binge patterns, the researchers said.
This week – the countdown toward the federal election – has been Mental Illness Awareness week. The cost of mental illness to the Canadian economy in terms of health care and lost productivity is estimated to be $51 billion a year. Given the absence of mental health and addiction issues from the campaign, it appears….
The government’s top medical adviser has drawn up plans for a minimum price for alcohol which would double the cost of some drinks in England. Under the proposal from Sir Liam Donaldson, it has been reported that no drinks could be sold for less than 50 pence per unit of alcohol they contain. It would….
Reckitt Benckiser Pharmaceuticals has launched Here to Help, an unique patient support program designed to improve outcomes for people in opioid dependence treatment with SUBOXONE (buprenorphine HCl/naloxone HCl dihydrate [2 mg/0.5 mg and 8 mg/2 mg]) C-III Sublingual Tablets. By focusing on coaching and education of patients and caregivers, Here to Help is designed to….
In 2006, excess alcohol use accounted for an estimated 80,000 deaths making alcoholism the third leading lifestyle-related cause of death in the United States, according to the Centers for Disease Control and Prevention. For each of these deaths, researchers estimate an average of 30 years of potential life lost per death due to excess alcohol….
A new study conducted on rodents has shown the extreme harm caused by chronic drinking on the liver, much more than the injury caused by binge drinking. Although alcohol consumption is known to cause liver damage, still the degree of liver damage can differ according to the pattern of drinking “Different patterns of drinking can]….
