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Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde. The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis.
The study contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed. The findings also may help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.
“Factors like binge drinking have been linked to increased risk for heart disease, and the newer inflammatory model is beginning to explain how,” study leader John Cullen, an assistant professor in the department of surgery, said in a medical center news release. “One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”
The study was published in the current issue of the journal Atherosclerosis.
Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism. Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.
An estimated 65 percent of Americans drink alcohol, and 15 percent reporting binge patterns, the researchers said.
Are you thinking about getting help for yourself or for someone you love who is addicted to drugs? Choosing the right substance abuse treatment for yourself or for someone you love can take time but the end result is well worth the effort. Taking a step back and looking at yourself, your lifestyle, your individual….
SEATTLE — A man who was denied a liver transplant largely because he used marijuana with medical approval to ease the symptoms of hepatitis C has died. Timothy Garon, 56, died Thursday at Bailey-Boushay House, an intensive care nursing center, said his lawyer, Douglas Hiatt, and Alisha Mark, a spokeswoman for Virginia Mason Medical Center,….
A Generation of Victorian teenagers are drinking themselves into oblivion, with more than a quarter of 15-year-olds bingeing until they black out – the point at which brain damage is likely to occur. Research has also found that more than a third of 11-year-old boys have consumed alcohol. The figures, contained in a study by….
Alcoholics who do not show they can stay sober outside hospital are expected to be offered liver transplants for the first time next month. A group of experts in liver disease will propose the change despite a shortage of organs. Under current guidelines, candidates for new livers have to show they can abstain from drink,….
Canadians are spending hundreds of millions of dollars every year self-medicating their insomnia with alcohol, a new study suggests. “We were very surprised to see that so many people use alcohol as a way to promote sleep, particularly because it has more detrimental than beneficial effects on sleep,” says Charles Morin, a professor of psychology….