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Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde. The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis.
The study contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed. The findings also may help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.
“Factors like binge drinking have been linked to increased risk for heart disease, and the newer inflammatory model is beginning to explain how,” study leader John Cullen, an assistant professor in the department of surgery, said in a medical center news release. “One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”
The study was published in the current issue of the journal Atherosclerosis.
Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism. Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.
An estimated 65 percent of Americans drink alcohol, and 15 percent reporting binge patterns, the researchers said.
Russian President Dmitry Medvedvev on Friday gave his officials three months to enact tough restrictions to try and curb alcohol abuse. Last month, Medvedev described alcoholism as a “national disaster”, which undermines public health and hampers the economy, urging the public to unite in fighting against it. Russia has one of the world’s highest per-capita….
A new study conducted on rodents has shown the extreme harm caused by chronic drinking on the liver, much more than the injury caused by binge drinking. Although alcohol consumption is known to cause liver damage, still the degree of liver damage can differ according to the pattern of drinking “Different patterns of drinking can]….
When Diane O’Connor adopted four children she had been fostering, she knew she had challenges ahead of her. Her previous experiences with foster children at her home in Upstate Albany had proven such kids often suffered from a variety of emotional and behavioral problems. This was understandable, given the abuse and neglect they had endured….
A few days before April, a young man, just 18 years old and a student at Waimea High School, was killed when he lost control of his pickup truck in the wee hours of a Sunday morning in Kekaha. His girlfriend was seriously injured and medivaced to O‘ahu for treatment. A press release from the….
Alcohol is by far the most widely abused drug in the entire world. Socially accepted and legal throughout the world, alcohol is the preferred drug of choice for millions of people across the world which is no wonder why so many people suffer from alcohol addiction. Unfortunately, individuals who drink alcohol regularly are subject to….
