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Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde. The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis.
The study contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed. The findings also may help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.
“Factors like binge drinking have been linked to increased risk for heart disease, and the newer inflammatory model is beginning to explain how,” study leader John Cullen, an assistant professor in the department of surgery, said in a medical center news release. “One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”
The study was published in the current issue of the journal Atherosclerosis.
Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism. Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.
An estimated 65 percent of Americans drink alcohol, and 15 percent reporting binge patterns, the researchers said.
More than 23.5 million people in the United States have had a problem with drugs or alcohol. Seven percent of those people are women. The United States has tens of thousands of facilities that are equipped to take care of the treatment needs of these women. When so many facilities are open and available to….
IT is a battle that all of us have to join hands and fight. Alcohol and drug abuse is on the increase in our society, especially among the youth. Young people should guard against becoming victims or risk being given a knockout by alcohol and drugs. Please stay clear of alcohol and drugs. We know….
Alcohol and drug addictions, in particular evolve out of the physical effects of ongoing substance abuse. While the substance and the physical effects it produces do account for the damage to a person’s life, the reasons that make him or her susceptible to addiction may very well lie at a deeper level. Christian rehab centers….
Russian President Dmitry Medvedvev on Friday gave his officials three months to enact tough restrictions to try and curb alcohol abuse. Last month, Medvedev described alcoholism as a “national disaster”, which undermines public health and hampers the economy, urging the public to unite in fighting against it. Russia has one of the world’s highest per-capita….
University of Texas-Pan American freshmen Iliana Cantu and Baldomero Perez giggled while taking a survey about alcohol use. The 18-year-olds said they don’t really drink and prefer to focus on their studies. “We’re geeks,” Perez joked. But they said they have friends attending schools beyond the Rio Grande Valley where binge drinking and heavy partying….
