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Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde. The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis.
The study contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed. The findings also may help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.
“Factors like binge drinking have been linked to increased risk for heart disease, and the newer inflammatory model is beginning to explain how,” study leader John Cullen, an assistant professor in the department of surgery, said in a medical center news release. “One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”
The study was published in the current issue of the journal Atherosclerosis.
Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism. Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.
An estimated 65 percent of Americans drink alcohol, and 15 percent reporting binge patterns, the researchers said.
People are drinking more alcohol by “stealth” because of the stronger drinks on the market, an analysis of consumption in the UK suggests. The amount of alcohol consumed per person has risen by 10% since 2000 – despite drink sales remaining steady. Researchers Mintel said wines and lagers were becoming stronger and people were unaware….
Alcoholism is a dangerous and deadly condition that affects thousands of Americans resulting in uncontrollable cravings to drink. Recent studies have found that Naltrexone can help to reduce the alcohol cravings that men and women have during alcohol treatment and help to reduce the chance of alcohol relapse. Treatment centers are now able to provide….
Mike was sober for 14 years. Then, at age 14, he took his first drink. And he drank until it defined him. First he called himself a drinker. Years later, when he was willing to admit it, he began using a new word: alcoholic. Mike (who asked that his last name not be printed) tried….
The decision to get needed alcohol abuse treatment often comes with more than a few concerns and doubts. No doubt, the alcohol-affected state of mind a person reaches by the time he or she considers getting treatment doesn’t make the process any easier. Of all the types of addiction treatment available, alcohol abuse treatment carries….
Pills that aimed to help people quit smoking, lose weight and kick other tough addictions, have been found to block the body’s pleasure centres, possibly raising the risk of depression and suicide. Margaret Bastian was among patients who reported problems with Chantix, a highly touted quit-smoking pill from Pfizer Inc, which has been linked to….
