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Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde. The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis.
The study contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed. The findings also may help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.
“Factors like binge drinking have been linked to increased risk for heart disease, and the newer inflammatory model is beginning to explain how,” study leader John Cullen, an assistant professor in the department of surgery, said in a medical center news release. “One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”
The study was published in the current issue of the journal Atherosclerosis.
Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism. Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.
An estimated 65 percent of Americans drink alcohol, and 15 percent reporting binge patterns, the researchers said.
Afghanistan supplies virtually all of the world’s illegal opium. Last year, the country’s drug trade was a $4-billion business, half of which alone was produced in the south where the fighting against the Taliban insurgency is the fiercest. Getting Afghanistan to rid itself of poppy is a pillar of U.S. policy there, because the Taliban….
Students desiring to excel at school or work may wish to forego binge drinking, research by Spanish scientists suggests. The study, published online ahead of print in the November issue of Alcoholism: Clinical & Experimental Research, finds binge drinkers expend more attentional effort to completing a given task, and have problems differentiating between relevant and….
Binge drinking in the military is more common than you may think, university study finds. It may come as no surprise to anyone who’s served in the military, but 43 percent of active-duty personnel admit to frequent binge drinking, according to a new study from the University of Minnesota. On average, that means that every….
In Dane County, more young people between seventh and 12th grades are abstaining from alcohol than regularly using it, according to a 2005 assessment. Still, the fact that nearly 30 percent of local youth are considered regular drinkers is a cause for concern for many. About 30 people turned out Monday night for the first….
Almost 89% of prisoners with an alcohol problem got no help while behind bars last year, according to figures obtained by The Herald. Despite alcohol being an aggravating factor in more than half of all homicides and much of the violent and anti-social crime which blights Scotland, a tiny proportion of inmates get specialist help….