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Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde. The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis.
The study contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed. The findings also may help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.
“Factors like binge drinking have been linked to increased risk for heart disease, and the newer inflammatory model is beginning to explain how,” study leader John Cullen, an assistant professor in the department of surgery, said in a medical center news release. “One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”
The study was published in the current issue of the journal Atherosclerosis.
Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism. Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.
An estimated 65 percent of Americans drink alcohol, and 15 percent reporting binge patterns, the researchers said.
Children who smoke cannabis are twice as likely to get into trouble – both in the classroom and outside the school gates. Boys turn to vandalism, theft and fights, while girls misbehave at school, a four-year study of thousands of pupils aged between 11 and 15 found. Young males are also up to twice as….
Jennifer Vanlieu was addicted to heroin and painkillers for some time before she found a methadone clinic that could help her beat the drug addiction and hopefully get her life back on track. What she didn’t know was that her decision to use methadone as a means of transitioning from being addicted to heroin to….
Co-occurring disorders, as the name suggests are the type of disorders that occur again. These disorders are mostly related to mental health problems and therefore the chance of the disorders affecting again is high in the patients who suffer mental imbalance or have self destructive tendencies or are impulsive in their behavior. The co-occurring….
When the vomiting, tremors, and chills she felt each morning became overwhelming, Jessica Polmann started selling her body to finance her heroin addiction and halt the debilitating physical symptoms of withdrawal. The petite, blond cheerleader, who made the honor roll before she started doing heroin at age 13, received $60 and some cigarettes each time….
Broward agency disputes it’s overstaffed and calls for review by consultants Broward County taxpayers could be spending too much to run a recovery center for drug addicts. A scathing report by county auditors last week charged that treatment at the Broward Addiction Recovery Center is about twice as costly as the national average. Too few….
