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Potential Drug Treatment for Alcoholism
A drug currently approved to treat bipolar disorder and schizophrenia may play a role in the treatment of alcoholism. The drug is called aripiprazole (Abilify); researchers say more research is needed, but this first study found the drug helps lessen the euphoric effects of alcohol.
Aripiprazole is a dopamine partial agonist, so it works differently in the body than other dopamine drugs. Study authors say the drug has different effects at different dose levels, so it is important to give the right amount of the drug to achieve the right results.
For the study, researchers recruited 18 social drinkers — nine men and nine women. Each participant completed three sessions in which they were given no medication, or 2.5 milligrams or 10 milligrams of aripiprazole. Then they were given three drinks and researchers measured their breath alcohol concentrations, heart rate, blood pressure, body sway and other subjective effects.
“Findings show that aripiprazole made the drinkers sleepier and they experienced less pleasure from alcohol than they might have without it,” says Henry Kranzler, a professor in the department of psychiatry at the University of Connecticut Health Center. Study authors say this is just preliminary research but one benefit might be that aripiprazole may be more tolerated than other drugs, causing fewer side effects. But researchers say that is still not proven and additional studies need to happen to determine if aripiprazole is a potential treatment for alcoholism.
_________ source: Alcoholism: Clinical & Experimental Research, 2008;32:573-578
A drug currently approved to treat bipolar disorder and schizophrenia may play a role in the treatment of alcoholism. The drug is called aripiprazole (Abilify); researchers say more research is needed, but this first study found the drug helps lessen the euphoric effects of alcohol. Aripiprazole is a dopamine partial agonist, so it works differently….
A recent study in Lancet Medical Journal says men are twice as likely as women to become alcoholics. Casual drinking may lead to something more serious. A study released this month shines a light on the risks of alcohol abuse, especially among those with a “Y” chromosome. The report says men are twice more likely….
The amount Britons drink has surged in recent decades, fuelled by plummeting prices and more women bingeing on alcohol. Awareness groups have warned for some time that consumption of alcohol is rising and that the number of booze-related deaths will continue to increase unless action is taken. Alison Rogers, chief executive of the British Liver….
John made it through Christmas with flying colors, though there was no hint of self-congratulation in his voice yesterday. But now New Year’s Eve is coming up, and for people like him the greatest hazards won’t be the ones lurking on the highways; they’ll be found in the gatherings of family and friends where someone’s….
Substance abuse is spreading rapidly around the world and the number of teens who do substance abuse is increasing at an alarming rate. Teenagers are widely using chemical substances for altering their “mood and physical state”. The use of chemical substances beyond the prescribed limit is bound to make the body of the user dependent….