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Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde. The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis.
The study contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed. The findings also may help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.
“Factors like binge drinking have been linked to increased risk for heart disease, and the newer inflammatory model is beginning to explain how,” study leader John Cullen, an assistant professor in the department of surgery, said in a medical center news release. “One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”
The study was published in the current issue of the journal Atherosclerosis.
Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism. Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.
An estimated 65 percent of Americans drink alcohol, and 15 percent reporting binge patterns, the researchers said.
New Year’s Eve celebrations can be synonymous with alcohol-fueled excess, or at least a champagne toast. But for those struggling with alcoholism, it’s a high-risk situation. Bradford Health Services Addiction Treatment administrator Timothy Robinson and community representative Amanda Lewis suggest techniques for staying sober and socially comfortable at a party where alcohol is served. HOW….
Prescription drug abuse is no longer a problem that only a certain generation or age group faces; rather it has become an epidemic, touching people of all walks of life. Many of the commonly abused prescription drugs are those that are prescribed for many health issues as well as recovery from those issues. Prescription drug abuse….
Cancer is a serious disease which is responsible for major percentage of deaths in the world. A cancer can affect any part of the body. Till date there are over 100 types of cancer which are being detected and are also treated. Anyone can get affected by the cancer, theirs no discrimination. Cancer is caused….
Cocaine is one of the most highly addictive drugs in existence. It increases energy and alertness and produces such an intense euphoria that, once tried, many find hard to resist. Cocaine Addiction We’ve all heard about the rat studies where rats are given the choice between food and cocaine and they always choose the cocaine….
Every year 3,000 women die as a result of alcohol, while binge drinking among British teens is rocketing. Here four women explain how alcohol has blighted their lives The Binge Drinker Dawn Morris, 27, lives in Watford with her husband James, 29, a promotions manager, her five-year-old son, Lewis, and two-year-old daughter, Isabella. “At college….
