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Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde. The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis.
The study contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed. The findings also may help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.
“Factors like binge drinking have been linked to increased risk for heart disease, and the newer inflammatory model is beginning to explain how,” study leader John Cullen, an assistant professor in the department of surgery, said in a medical center news release. “One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”
The study was published in the current issue of the journal Atherosclerosis.
Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism. Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.
An estimated 65 percent of Americans drink alcohol, and 15 percent reporting binge patterns, the researchers said.
A no-frills bar called Goober’s, just north of Providence, Rhode Island, is probably the last place you’d expect to find a debate over cutting-edge addiction therapy. But this is where Walter Kent, a retired mechanic, spends his Fridays. He helps in the kitchen and hangs out in the bar, catching up with old friends. Most….
Did you know that your support system can make all the difference when you enter into drug treatment? The social support systems that are integrated into drug treatment programs can have dramatic effects on the success of the overall treatment program, especially for those whose addictions are highly psychological in matter. A strong social support….
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Think of it as a breathalyzer you wear. SCRAM is a relatively new piece of technology, designed to keep people sober. The device is being shown this week to a Nashville audience. A DUI could be enough to scare a driver sober, but one small device will make one stay that way. “Literally, if you….
When you’re addicted to drugs, finding and choosing the right drug treatment center may be not only difficult it could be a challenge that you cannot even begin to fathom. Drug addiction takes everything out of you and is physically, emotionally, spiritually and even financially exhausting. Choosing the right drug treatment center is not only….