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Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde. The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis.
The study contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed. The findings also may help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.
“Factors like binge drinking have been linked to increased risk for heart disease, and the newer inflammatory model is beginning to explain how,” study leader John Cullen, an assistant professor in the department of surgery, said in a medical center news release. “One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”
The study was published in the current issue of the journal Atherosclerosis.
Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism. Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.
An estimated 65 percent of Americans drink alcohol, and 15 percent reporting binge patterns, the researchers said.
I had an interesting Blog Comment from Pavel Nepustil, a Czech republic NGO worker and PhD student, currently in Houston, USA, on a Fullbright Scholarship. Pavel came over to see us in Cardiff last year and we decided we would work together. He is one bright ‘cookie’ and very dedicated to this field. He got….
ONE in every seven hospital beds in the Lothians is taken up by a patient who is ill through alcohol abuse, it has emerged. The statistic is the latest stark illustration of the rising cost of alcohol abuse to the NHS. Included in the tens of thousands of people occupying beds in the ERI every….
The state of Florida has long been a major gateway for moving illegal drugs into and throughout the United States. Add to this Florida’s proximity to drug-producing countries and ongoing shipment hauls and it’s no wonder substance abuse rates continue to climb within the state. Fortunately, anyone who finds him or herself battling a drug….
If you are looking for a drug treatment center that can provide you or a loved one with treatment for any type of drug addiction then chances are you have already fallen victim to the many myths of drug treatment. Unfortunately, there is much confusion that surrounds drug treatment but the myths of drug treatment….
There are more than 800 over-the-counter cold and cough medications. It is a huge and profitable industry, with an excess of $2 billion spent each year nationwide. Because they are sold without a prescription, many people assume the medications are “safe.” These medications are associated with potentially serious side effects. Many products contain multiple substances….