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Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde. The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis.
The study contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed. The findings also may help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.
“Factors like binge drinking have been linked to increased risk for heart disease, and the newer inflammatory model is beginning to explain how,” study leader John Cullen, an assistant professor in the department of surgery, said in a medical center news release. “One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”
The study was published in the current issue of the journal Atherosclerosis.
Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism. Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.
An estimated 65 percent of Americans drink alcohol, and 15 percent reporting binge patterns, the researchers said.
Low bone mass, or osteoporosis, is a known consequence of alcoholism, especially in older alcoholics. However, a new study shows that younger male alcoholics are also at increased risk for osteoporosis. People with osteoporosis, no matter what the cause, are at an increased risk for fractures and poor fracture healing. “Our study indicates malnutrition, little….
FRAMINGHAM, Mass. — Facing a dozen strangers seated around a table, the heavyset man with thinning hair put down his coffee and paused before introducing himself: “My name is Christian. And I’m a compulsive overeater.” For the next hour, members of the MetroWest Intergroup of Overeaters Anonymous shared personal stories of long-term weight gain and….
When Rosalie Cebreros went out with friends Thursday evening, she found herself in a place she least expected: the Addiction Recovery Center. It wasn’t even the freshman’s first visit to the ARC this fall semester. Cebreros, an open-option major, spoke from the audience about her experience with excessive alcohol consumption during a panel discussion on….
Deciding to seek help for alcoholism is the very first step to finally recovering from a dangerous and deadly addiction to alcohol, but it’s also one of the most difficult decisions you will ever make. Choosing between the many alcoholism treatment centers that are available to help you or a loved one overcome addiction is….
People who socialize with heavy drinkers are more likely to imbibe a bit too much themselves. And the same holds true for teetotalers: Those who have non-drinking friends and relatives are more likely not to consume alcohol themselves, a new study found. “People are organized by their drinking behavior more than would be predicted by….