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Potential Drug Treatment for Alcoholism
A drug currently approved to treat bipolar disorder and schizophrenia may play a role in the treatment of alcoholism. The drug is called aripiprazole (Abilify); researchers say more research is needed, but this first study found the drug helps lessen the euphoric effects of alcohol.
Aripiprazole is a dopamine partial agonist, so it works differently in the body than other dopamine drugs. Study authors say the drug has different effects at different dose levels, so it is important to give the right amount of the drug to achieve the right results.
For the study, researchers recruited 18 social drinkers — nine men and nine women. Each participant completed three sessions in which they were given no medication, or 2.5 milligrams or 10 milligrams of aripiprazole. Then they were given three drinks and researchers measured their breath alcohol concentrations, heart rate, blood pressure, body sway and other subjective effects.
“Findings show that aripiprazole made the drinkers sleepier and they experienced less pleasure from alcohol than they might have without it,” says Henry Kranzler, a professor in the department of psychiatry at the University of Connecticut Health Center. Study authors say this is just preliminary research but one benefit might be that aripiprazole may be more tolerated than other drugs, causing fewer side effects. But researchers say that is still not proven and additional studies need to happen to determine if aripiprazole is a potential treatment for alcoholism.
_________ source: Alcoholism: Clinical & Experimental Research, 2008;32:573-578
University of Texas-Pan American freshmen Iliana Cantu and Baldomero Perez giggled while taking a survey about alcohol use. The 18-year-olds said they don’t really drink and prefer to focus on their studies. “We’re geeks,” Perez joked. But they said they have friends attending schools beyond the Rio Grande Valley where binge drinking and heavy partying….
Oregon Health & Science University Cancer Institute researchers have pinpointed the protein that can lead to genetic changes that cause lung cancer. Researchers discovered that the production of a protein called FANCD2 is slowed when lung cells are exposed to cigarette smoke. Low levels of FANCD2 leads to DNA damage, triggering cancer. Cigarette smoke curbs….
When most people think about the upcoming holidays, they think about friends, family, food and good cheer. But for many people, the weeks between Thanksgiving and New Year’s are particularly difficult. Financial problems are tough to handle at any time, but they can seem overwhelming during this season of giving. Feelings of loneliness, isolation and….
If you think you drink too much, and you are not content with that, then you need to take action. Nobody can force you to reduce your alcohol intake, or make you seek professional help. The only person who can take responsibility for your drinking is YOU. No one else can change your lifestyle, but….
Five or more drinks a day at one sitting affects 23 percent of men ages 50 to 64, reports Duke University researchers. We don’t usually associate binge drinking, that is guzzling large quantities of alcoholic beverages in one sitting, with older people. Instead it is usually considered a college rite of passage. But a new….
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