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Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde. The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis.
The study contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed. The findings also may help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.
“Factors like binge drinking have been linked to increased risk for heart disease, and the newer inflammatory model is beginning to explain how,” study leader John Cullen, an assistant professor in the department of surgery, said in a medical center news release. “One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”
The study was published in the current issue of the journal Atherosclerosis.
Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism. Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.
An estimated 65 percent of Americans drink alcohol, and 15 percent reporting binge patterns, the researchers said.
The Anchorage division of RuralCap is negotiating to buy a Red Roof Inn at Fifth Avenue and Karluk Street. The agency is seeking a state grant through the Alaska Housing Finance Corp. The Anchorage Daily News reported Monday the effort would follow a housing program in Seattle that does not require residents to stop drinking…..
Starting at Age 15 Increases Risk Six Times over Waiting Until 21 State Office of Alcoholism and Substance Abuse Services (OASAS) Commissioner Karen M. Carpenter-Palumbo today recognized Alcohol Awareness Month calling on parents to help prevent underage drinking by learning the facts about alcohol and how they can take action to stop the early onset….
You may think that private addiction treatment is too expensive, that you can’t afford it or that it can’t possibly be that much better than a similar public treatment program but do you know the true value of private addiction treatment? Do you know that private addiction treatment is your best chance at getting the….
A SuperJob.ru survey says most Russians believe alcohol abuse is their most negative character trait(!). 22% of 1800 respondents believe it is so, while 20% claim Russians’ curse is their laziness. Boozing has become something of a national character trait in Russia. Although statistics shows that alcohol consumption has been annually reducing in Russia, stories….
Buried on page 795 of President Obama’s budget, released last Thursday, is a paragraph banning the federal funding of needle-exchange programs for drug addicts — an apparent about-face on his campaign promise to overturn that longstanding ban. To the further consternation of AIDS and addiction activists, a statement of support for needle exchange was recently….