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Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde. The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis.
The study contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed. The findings also may help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.
“Factors like binge drinking have been linked to increased risk for heart disease, and the newer inflammatory model is beginning to explain how,” study leader John Cullen, an assistant professor in the department of surgery, said in a medical center news release. “One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”
The study was published in the current issue of the journal Atherosclerosis.
Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism. Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.
An estimated 65 percent of Americans drink alcohol, and 15 percent reporting binge patterns, the researchers said.
Researchers at Boston University School of Medicine (BUSM) have found that heavier intrauterine cocaine exposure (IUCE) is associated with mild compromise on selective areas of neurocognitive development during middle childhood. The BUSM study appears in the May issue of Neurotoxicology and Teratology. BUSM researchers evaluated whether the level of IUCE or the interaction between IUCE….
There are all types of treatment centers available and they each have their own benefits. Private drug treatment centers have the primary advantages of being private, providing luxury amenities, and being located in some of the best locations of the world. If you’re not sure what private drug treatment centers really have to offer, consider….
Nova Scotia still has a drinking problem. People in the province still drive drunk, still go on benders at bars, still drink underage and some drink while pregnant. To combat this, last August the provincial Department of Health Promotion and Protection launched a strategy called Changing the Culture of Alcohol Use in Nova Scotia. Almost….
Faith-based organizations continue to meet vital social needs within communities across the country. According to the Manhattan Institute, faith-based organizations contribute an estimated $20 billion in private funding to social service agencies on an annual basis. With alcoholism a continuing social problem within the U.S., Christian alcohol treatment centers offer a multi-faceted treatment approach to….
SEATTLE — A man who was denied a liver transplant largely because he used marijuana with medical approval to ease the symptoms of hepatitis C has died. Timothy Garon, 56, died Thursday at Bailey-Boushay House, an intensive care nursing center, said his lawyer, Douglas Hiatt, and Alisha Mark, a spokeswoman for Virginia Mason Medical Center,….