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Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde. The Rochester team found that binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis.
The study contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed. The findings also may help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.
“Factors like binge drinking have been linked to increased risk for heart disease, and the newer inflammatory model is beginning to explain how,” study leader John Cullen, an assistant professor in the department of surgery, said in a medical center news release. “One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”
The study was published in the current issue of the journal Atherosclerosis.
Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism. Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.
An estimated 65 percent of Americans drink alcohol, and 15 percent reporting binge patterns, the researchers said.
It is a long-observed conclusion that many people with substance abuse problems also have mental health issues. The debate often rests on whether or not one causes the other and if treatment of one can make the other disappear. This can be a heated topic, as some experts insist on treating both as co-occurring disorders,….
There are many benefits to private addiction treatment but that doesn’t necessarily mean that this method of treatment is the right action for everyone who is addicted to drugs or alcohol. Many people cannot afford private addiction treatment and for others, the utmost privacy that is provided in these programs is simply more than necessary….
Researchers at the McGill University Health Centre (MUHC), McGill University and the University of British Columbia (UBC) determined that medical use of cannabinoids do not cause an increase in serious adverse events, but are associated with an increase in some non-serious adverse events. Several drugs containing compounds derived from the cannabis plant, or cannibinoids, are….
Not everyone drinks in response to stress. A number of factors, including genetics, usual drinking behavior, experiences with alcohol or other drugs, and social support, help determine whether a person will drink during a stressful situation. Does drinking help people relax? Researchers aren’t quite sure. According to the National Institute on Alcohol Abuse and Alcoholism,….
The chapel at Immanuel Presbyterian Church was filled to capacity last Saturday afternoon, with mourners moving up to the balcony. Much to the surprise of his family, hundreds — from infants to senior citizens — came to honor John Robert McGraham, a homeless man who was brutally murdered on Oct. 9. McGraham, 55, was doused….